V3I3P84

Antibacterial Efficacy of Mangiferin in Mango (Mangifera indica) Peel Extract Against Staphylococcus aureus

Christian Kelvin D. Sampani^1*, Cefer S. Sales¹, Henry F. Haranay²

Abstract

This study examines the antibacterial activity of the mango (Mangifera indica) peel extract, focusing on its key bioactive compound mangiferin against Staphylococcus aureus. It is in an attempt to examine its effectiveness as a natural alternative to conventional antibiotics. The procedure used to find antibacterial activity of mango peel extract was agar well diffusion technique which compared different inhibition zone of different concentrations (50% and 100%) and positive (Cefoxitin) and negative (distilled water) controls. Results showed that the positive control exhibited the largest inhibition zone (27.0 mm), while the negative control showed no inhibition (0.0 mm). The 100% extract of mango peel yielded a mean inhibition zone of 18.0 mm, indicating a strong antibacterial potential, which is considered as high, and the 50% extract of mango peel yielded a moderate effect of 13.7 mm inhibition zone. Using One-Way ANOVA (F=59.895, p=0.000) proved that there are significant differences between the treatments. The 100% and 50% concentrations both showed a significant difference to the negative control (p=0.000) as shown by a post hoc analysis. Although, the activity of the 100% concentration was statistically significant compared with the positive control (p=0.002), the difference between the 100% and 50% concentration was not statistically significant (p=0.068). The trend shows a dose-dependent effect. This study implies that mango peel extract, due to the bioactive compounds such as mangiferin, especially at a higher concentration, has a great potential to be considered as a natural, economical and sustainable alternative against S. aureus.

Keywords:

Mangifera indica, Antibacterial activity, Staphylococcus aureus, Inhibition zone, Gram-positive bacterium