V3I10P49

Transdermal Drug Delivery System

Syed Afshan Roohi¹*, L Mohan Krishna², Shaik Shabana Tabassum¹, Shaik Ramzanbee¹, Shaik Shabu¹

Abstract

Transdermal drug delivery systems (TDDS) represent an alternative route of drug administration. Active pharmaceutical ingredients (APIs) are delivered to the systemic circulation across the skin. It may be of advantage over conventional oral drug administration. However, the outer layer of the skin, the stratum corneum, represents a barrier to the penetration of drugs. Recent advances in drug delivery through patches have focused on the development of microneedles and nanocarriers to improve the penetration of drugs and their stability in the skin. This review discusses the basic principles of TDDS, selected FDA-approved transdermal products, and emerging approaches involving microneedles and nanocarriers. It also highlights current formulation challenges, safety considerations, and future research directions. Although these technologies show promise, their clinical usefulness depends on further evaluation of efficacy, safety, manufacturing consistency, and regulatory requirements.^1,2

Keywords:

Matrix patch, skin permeation; drug delivery system; permeation enhancer; microneedle; nanocarriers; iontophoresis.